St. Francis Medical Center was founded in 1874 by the Sisters of St. Francis of Philadelphia as Trenton’s first hospital. Today, it is an acute care teaching hospital with more than 300 medical staff physicians representing all specialties and a member of the Trinity Health System. Trinity Health is one of the largest multi-institutional Catholic health care delivery systems in the nation. It serves people and communities in 21 states with 86 hospitals, 109 continuing care facilities and home health and hospice programs that provide nearly 2.8 million visits annually.

Trenton is located in Mercer County and is the capital of the state of New Jersey. The town borders the Delaware River. The city was created within the Trenton Township in 1792. The municipality contains the distinct neighborhoods known as North Ward, South Ward, East Ward and West Ward. "The island" is another noteworthy area in Trenton and the historic Mill Hill is located near downtown.

The New Jersey Transit provides extensive bus transportation for the city and the nearby suburbs. Train service emanating from Trenton Rail Station runs along the Northeast Corridor and connects the city with Newark as well as New York. SEPTA offers train service which begins at the Trenton Station and runs by the side of the Northeast Corridor and connects with Philadelphia. The Trenton-Mercer Airport offers limited air transportation.